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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

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Mouse Genome Database: From sequence to phenotypes and disease models.

Janan T Eppig¹, Joel E Richardson¹, James A Kadin¹

¹The Jackson Laboratory, Bar Harbor, Maine.

Genesis (New York, N.Y. : 2000)

|July 8, 2015

Summary

This summary is machine-generated.

The Mouse Genome Database (MGD) is a vital resource for biomedical research, offering comprehensive genetic and genomic data on laboratory mice. It standardizes nomenclature and integrates diverse datasets to advance scientific discovery.

Keywords:

database gene function genomics human disease models mouse

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Area of Science:

Genomics
Bioinformatics
Mammalian Genetics

Background:

The Mouse Genome Database (MGD) is a key international resource for the biomedical community.
It provides essential genetic, genomic, and biological data for laboratory mice.
Accurate and integrated data is crucial for advancing research.

Purpose of the Study:

To describe the Mouse Genome Database (MGD) and its functionalities.
To highlight MGD's role in standardizing mouse nomenclature and data curation.
To detail the data acquisition, key data areas, access methods, and user support.

Main Methods:

Data acquisition from literature and electronic sources.
Curation and integration of diverse biological datasets.
Development of standardized nomenclature for mouse genes, mutants, and strains.

Main Results:

MGD offers a comprehensive catalog of mouse genes and genome features.
It provides authoritative Gene Ontology (GO) annotations for mouse gene functions.
MGD includes extensive data on mouse mutations, phenotypes, and models of human diseases.

Conclusions:

MGD serves as an authoritative standard for mouse genetic and genomic information.
The database facilitates research by providing integrated and accessible data.
MGD supports the biomedical community through comprehensive data and user resources.