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Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

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Hereditary diffuse gastric cancer--An overview.

Simona Gurzu¹, Ioan Jung¹, Janina Orlowska²

¹Department of Pathology, University of Medicine and Pharmacy of Tirgu-Mures, Romania.

Pathology, Research and Practice

|July 8, 2015

Summary

Hereditary diffuse gastric cancer (HDGC) accounts for 3% of all gastric cancers. This review details HDGC characteristics, geographic distribution, and genetic counseling strategies for affected families.

Keywords:

Adductomics Ethnic difference Geographic distribution Hereditary gastric cancer

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Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

Area of Science:

Oncology
Genetics
Carcinogenesis

Background:

Gastric cancer incidence varies globally, with hereditary cases poorly understood.
Familial clustering affects 10% of gastric cancer cases.
Hereditary diffuse gastric cancer (HDGC) accounts for approximately 3% of all gastric cancers.

Purpose of the Study:

To present the characteristics of HDGC, including molecular aspects and geographic distribution.
To explore the potential of mutation signature and adductomic studies in HDGC carcinogenesis.
To provide an updated review of genetic counseling, screening, and surveillance for HDGC families.

Main Methods:

Literature review and synthesis of existing data on HDGC.
Discussion of molecular particularities and geographic distribution.
Exploration of novel approaches like mutation signature and adductomic studies.

Main Results:

HDGC exhibits distinct molecular characteristics and a specific geographic distribution.
Genetic counseling and surveillance protocols are crucial for managing HDGC.
Mutation signature and adductomic studies offer potential insights into HDGC carcinogenesis.

Conclusions:

Understanding HDGC's molecular and geographic factors is vital.
Comprehensive genetic counseling and surveillance are essential for early detection and management.
Further research into mutation signatures and adductomics may elucidate HDGC development.