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Breeder differences within Wistar strain rats in step-through type passive avoidance response.

K Hirate1, H Kuribara, S Tadokoro

  • 1Division for Behavior Analysis, Gunma University School of Medicine, Japan.

Japanese Journal of Pharmacology
|December 1, 1989
PubMed
Summary
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Wistar rats from different breeders show significant variations in passive avoidance learning and memory. These findings highlight crucial genetic differences impacting behavioral responses, even within the same rat strain.

Area of Science:

  • Neuroscience
  • Animal Behavior
  • Genetics

Background:

  • Passive avoidance behavior is a key indicator of learning and memory in rodents.
  • Wistar rats are commonly used in research, but genetic variability between breeders may influence experimental outcomes.

Purpose of the Study:

  • To investigate the acquisition and retention of passive avoidance responses in different Wistar rat lines and F344/Du Crj rats.
  • To identify potential breeder-specific differences in passive avoidance behavior.

Main Methods:

  • Utilized a step-through passive avoidance task involving one-trial and repeated-training protocols.
  • Compared latency times for entering a dark chamber from an illuminated runway across different rat lines (HLA:Wistar, JLA:Wistar, Std:Wistar) and a separate strain (F344/Du Crj).

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Main Results:

  • Std:Wistar rats exhibited longer latencies in initial trials, suggesting slower adaptation.
  • JLA:Wistar rats demonstrated poorer acquisition and retention, requiring more trials to remain in the runway and showing shorter retention latencies.
  • Response latencies in retention trials followed the order: HLA:Wistar ≥ F344/Du Crj > Std:Wistar > JLA:Wistar.

Conclusions:

  • Significant breeder-dependent differences exist in the passive avoidance response of Wistar rats.
  • These genetic variations can substantially impact learning and memory capabilities, underscoring the importance of specifying rat origin in research.