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Updated: Apr 7, 2026

Analysis of Protein-protein Interactions and Co-localization Between Components of Gap, Tight, and Adherens Junctions in Murine Mammary Glands
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Physiological roles of connexins in labour and lactation

Gerald M Kidder1, Elke Winterhager2

  • 1Department of Physiology and PharmacologySchulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario N6A 5C1, CanadaInstitute of Molecular BiologyUniversity of Duisburg-Essen, University Clinics, 45211 Essen, Germany gmk@uwo.ca.

Reproduction (Cambridge, England)
|July 8, 2015
PubMed

The connexin family of proteins are best known as oligomerizing to form intercellular membrane channels (gap junctions) that metabolically and ionically couple cells to allow for coordinated cellular function. Nowhere in the body is this role better illustrated than in the uterine smooth muscle during parturition, where gap junctions conduct the contraction wave throughout the tissue to deliver the baby. Parturition is followed by the onset of lactation with connexins contributing to both the dramatic reorganization of mammary gland tissue leading up to lactation and the smooth muscle contraction of the myoepithelial cells which extrudes the milk. This review summarizes what is known about the expression and roles of individual connexin family members in the uterus during labour and in the mammary glands during development and lactation. Connexin loss or malfunction in mammary glands and the uterus can have serious implications for the health of both the mother and the newborn baby.

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