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Updated: Apr 7, 2026

Mosaic Zebrafish Transgenesis for Functional Genomic Analysis of Candidate Cooperative Genes in Tumor Pathogenesis
Published on: March 31, 2015
BRAF gene: From human cancers to developmental syndromes
Muhammad Ramzan Manwar Hussain1, Mukhtiar Baig2, Hussein Sheik Ali Mohamoud3
1Faculty of Genetic Medicine, King Abdulaziz University, Jeddah, Saudi Arabia ; CAS-Institute of microbiology, University of Chinese Academy of Sciences, Beijing, China.
Abstract:
The BRAF gene encodes for a serine/threonine protein kinase that participates in the MAPK/ERK signalling pathway and plays a vital role in cancers and developmental syndromes (RASopathies). The current review discusses the clinical significance of the BRAF gene and other members of RAS/RAF cascade in human cancers and RAS/MAPK syndromes, and focuses the molecular basis and clinical genetics of BRAF to better understand its parallel involvement in both tumourigenesis and RAS/MAPK syndromes-Noonan syndrome, cardio-facio-cutaneous syndrome and LEOPARD syndrome.
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