Genomic basis of evolutionary change: evolving immunity
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Updated: Apr 7, 2026

Inoculating Anopheles gambiae Mosquitoes with Beads to Induce and Measure the Melanization Immune Response
Published on: January 12, 2017
1Groningen Institute for Evolutionary Life Sciences, University of Groningen , Groningen, Netherlands.
Abstract:
Complex traits are manifestations of intricate gene interaction networks. Evolution of complex traits revolves around the genetic variation in such networks. Genomics has increased our ability to investigate the complex gene interaction networks, and characterize the extent of genetic variation in these networks. Immunity is a complex trait, for which the ecological drivers and molecular networks are fairly well understood in Drosophila. By characterizing the natural variation in immunity, and mapping how the genome changes during the evolution of immunity in Drosophila, we can integrate our knowledge on the complex genetic architecture of traits and the molecular basis of evolutionary processes.
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