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[Therapy of chronic recurrent respiratory tract infections]
Abstract:
In 1987, the most frequently identified pathogens in chronic respiratory tract infections in our clinic were Haemophilus influenzae, Pseudomonas aeruginosa, Branhamella catarrhalis, Streptococcus pneumoniae, Staphylococcus aureus and Klebsiella pneumoniae. Recurrent infection is a common phenomenon in patients with chronic respiratory tract infections, including chronic bronchitis, chronic bronchiolitis and bronchiectasis. H. influenzae is the most common pathogen in such patients. Macrolides, tetracyclines and new quinolones were effective to protect against recurrent infection of H. influenzae and these finding suggested that L-forms of H. influenzae may be significant in the recurrence of infection in patients with chronic respiratory tract infection. Bacterial colonization of the oropharynx is the initial event in most lower respiratory tract infections. Gargling protects against bacteria colonization of the oropharynx and occurrence of acute exacerbation.
Insights
Haemophilus influenzae is a common cause of recurrent respiratory infections. Treatments like macrolides and quinolones show effectiveness, suggesting L-forms may play a role in chronic infections.
Area of Science:
- Infectious Diseases
- Microbiology
- Pulmonology
Background:
- Chronic respiratory tract infections (CRTI) are frequently recurrent.
- Common pathogens include Haemophilus influenzae, Pseudomonas aeruginosa, and Staphylococcus aureus.
- Haemophilus influenzae is the most prevalent pathogen in CRTI.
Purpose of the Study:
- To identify common pathogens in CRTI.
- To evaluate the effectiveness of antibiotics against recurrent H. influenzae infections.
- To investigate the potential role of L-forms in CRTI recurrence.
Main Methods:
- Retrospective analysis of identified pathogens in CRTI patients from 1987.
- Assessment of antibiotic efficacy (macrolides, tetracyclines, new quinolones) against H. influenzae.
- Exploration of L-form significance in recurrent infections.
Main Results:
- Haemophilus influenzae, Pseudomonas aeruginosa, and Staphylococcus aureus were frequently identified.
- Macrolides, tetracyclines, and new quinolones demonstrated effectiveness against recurrent H. influenzae infections.
- Findings suggest L-forms of H. influenzae may contribute to CRTI recurrence.
Conclusions:
- Haemophilus influenzae is a key pathogen in CRTI.
- Antibiotic treatment can prevent recurrent H. influenzae infections.
- L-forms of H. influenzae warrant further investigation for their role in chronic respiratory infections.