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Mean platelet volume and left ventricular geometry in patients with aortic valve stenosis

Satoshi Kurisu1, Tadanao Higaki1, Hiroki Ikenaga1

  • 1a Department of Cardiovascular Medicine , Hiroshima University Graduate School of Biomedical and Health Sciences , Hiroshima , Japan.

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|July 8, 2015
PubMed

Insights

Mean platelet volume (MPV) was elevated in patients with aortic valve stenosis (AS), correlating with disease severity. However, MPV did not reflect left ventricular geometry changes in these patients.

Area of Science:

  • Cardiology
  • Hematology
  • Biomarkers

Background:

  • Mean platelet volume (MPV) is a recognized indicator of platelet activation.
  • Platelet activation markers may be relevant in cardiovascular diseases like aortic valve stenosis (AS).

Purpose of the Study:

  • To compare MPV levels between patients with AS and healthy controls.
  • To investigate the relationship between MPV and left ventricular geometry in AS patients.

Main Methods:

  • MPV was measured in 75 AS patients and 38 age/sex-matched controls.
  • Peak pressure gradient and left ventricular geometry were assessed in AS patients.

Main Results:

  • MPV was significantly higher in AS patients compared to controls (10.57 ± 1.05 fl vs. 9.72 ± 0.66 fl, p < 0.001).
  • A positive correlation was found between peak pressure gradient and MPV in AS patients (r = 0.35, p < 0.001).
  • No significant association was observed between MPV and left ventricular geometry (including LVM index) across different geometric groups.

Conclusions:

  • MPV is elevated in patients with AS and correlates with stenosis severity.
  • MPV does not appear to be a reliable indicator of left ventricular geometry in AS.
Abstract

Keywords:
Aortic valveplateletventricular hypertrophy

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