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Updated: Apr 7, 2026

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides
Published on: November 21, 2013
Supramolecular Assemblies Responsive to Biomolecules toward Biological Applications
Hajime Shigemitsu1, Itaru Hamachi2,3
1Department of Synthetic Chemistry and Biological Chemistry, Graduated School of Engineering, Kyoto University, Katsura, Kyoto, 615-8510, Japan.
Stimuli-responsive supramolecular assemblies offer dynamic and reversible properties for diverse biological applications. Recent advances show these assemblies can function within live cells, expanding their potential in chemical biology and biofunctional materials.
Area of Science:
- Supramolecular Chemistry
- Chemical Biology
- Materials Science
Background:
- Stimuli-responsive supramolecular assemblies are versatile materials for biological applications like drug delivery and diagnostics.
- Their dynamic and reversible nature allows for tailored responses to various biomolecules.
- Recent research highlights their potential utility within live cellular environments.
Purpose of the Study:
- To review strategies for constructing dynamic supramolecular assemblies responsive to biomolecules.
- To explore the functions and applications of these assemblies in biological systems.
- To discuss the emerging potential of supramolecular assemblies in live-cell applications.
Main Methods:
- Review of literature on stimuli-responsive supramolecular assemblies.
- Analysis of design strategies for biomolecule-responsive systems.
- Examination of in vitro and in vivo studies of supramolecular assembly functions.
Main Results:
- Various strategies exist for creating dynamic supramolecular assemblies responsive to specific biomolecules.
- These assemblies demonstrate potential in drug delivery, diagnostics, enzyme immobilization, and tissue engineering.
- Emerging evidence confirms the functionality of some supramolecular assemblies within live cells.
Conclusions:
- Biomolecule-responsive supramolecular assemblies are promising for advanced biological applications.
- Their ability to function in live cells opens new frontiers in chemical biology.
- Further development of these dynamic materials will drive innovation in biofunctional materials and therapies.
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