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Published on: February 12, 2017
MicroRNA-34c-5p is related to recurrence in laryngeal squamous cell carcinoma
Massimo Re1, Artan Çeka2, Corrado Rubini3
1Department of Otorhinolaryngology, Umberto I University General Hospital, Polytechnic University of the Marches, Ancona, Italy.
Objectives/Hypothesis:
Altered microRNA expression has been found in many cancer types, including laryngeal squamous cell carcinoma (LSCC). We investigated the association of LSCC-related miR-34c-5p with disease-free survival and overall survival.
Study Design:
Retrospective cohort study.
Methods:
Expression levels of miR-34c-5p were detected in 90 LSCC formalin-fixed paraffin-embedded tissues by reverse-transcription quantitative polymerase chain reaction. Overall survival and disease-free survival were evaluated using the Kaplan-Meier method, and multivariate analysis was performed using Cox proportional hazard analysis.
Results:
A downregulation of miR-34c-5p expression significantly correlated with worse disease-free and overall survival. In the multivariate analysis, low miR-34c-5p expression was associated with an increased risk of recurrence.
Conclusions:
A downregulation of miR-34c-5p in LSCC is independently associated with unfavorable disease-free survival, suggesting that miR-34c-5p might be a promising marker for evaluating the risk of recurrences.
Level Of Evidence:
NA.
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