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Updated: Apr 7, 2026

A Free-breathing fMRI Method to Study Human Olfactory Function
Published on: July 30, 2017
Rapidly fluctuating anosmia: A clinical sign for unilateral smell impairment
Simona Negoias1, Hergen Friedrich1, Marco D Caversaccio1
1Department of Otorhinolaryngology-Head and Neck Surgery, Bern University Hospital, Bern, Switzerland.
Abstract:
Reports about fluctuating olfactory deficits are rare, as are reports of unilateral olfactory loss. We present a case of unilateral anosmia with contralateral normosmia, presenting as rapidly fluctuating anosmia. The olfactory fluctuation occurred in sync with the average nasal cycle duration. Examination after nasal decongestion, formal smell testing, and imaging revealed unilateral, left-sided anosmia of sinonasal cause, with right-sided normosmia. We hypothesize that the nasal cycle induced transient anosmia when blocking the normosmic side. Fluctuating olfactory deficits might hide a unilateral olfactory loss and require additional unilateral testing and thorough workup.
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