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Related Experiment Video

Updated: Apr 7, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Pacemaker lead-associated thrombosis in cardiac resynchronisation therapy.

Jesmar Buttigieg¹, Rachelle Asciak², Charles Mallia Azzopardi³

¹Department of Medicine, Mater Dei Hospital, Malta, Msida, Malta.

BMJ Case Reports

|July 9, 2015

Summary

Pacemaker lead-associated thrombosis, a rare complication of cardiac resynchronisation therapy, was identified in a patient presenting with non-specific symptoms. Surgical removal of the sterile thrombus and pacing device led to an uncomplicated recovery.

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Area of Science:

Cardiology
Medical Devices
Thrombosis Research

Background:

Pacemaker lead-associated thrombosis is a recognized complication of cardiac implantable electronic devices.
Cardiac resynchronisation therapy (CRT) is used for heart failure management.
Device-related complications require careful diagnosis and management.

Observation:

A middle-aged woman with ischemic left ventricular failure presented with fever 4 months post-CRT.
Transesophageal echocardiogram revealed a vegetation-like mass on the right atrial pacemaker lead.
The mass was initially suspected to be infected but later confirmed as sterile thrombus.

Findings:

The patient underwent successful surgical removal of the thrombus and pacing system.
Histopathology and cultures confirmed a sterile thrombus, ruling out infective endocarditis.
The patient experienced an uncomplicated recovery with no long-term sequelae.

Implications:

This case highlights the importance of considering sterile thrombus formation on pacemaker leads.
Prompt diagnosis and surgical intervention are crucial for managing such complications.
Successful management can lead to favorable long-term outcomes in patients with cardiac implantable devices.