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Association between arsenic exposure and thyroid function: data from NHANES 2007-2010.

Ram B Jain1

  • 1a Private Consultant , Sanford , NC , USA.

International Journal of Environmental Health Research
|July 9, 2015
PubMed
Summary

Arsenic exposure, specifically dimethylarsinic acid (UDMA), impacts thyroid function. Higher UDMA levels correlate with altered thyroid-stimulating hormone (TSH) and thyroxine (TT4) in males and females, suggesting a link between arsenic and thyroid health.

Keywords:
arsenobetainedimethylarsinic acidiodine sufficiencysmoking

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Area of Science:

  • Environmental Health
  • Endocrinology
  • Toxicology

Background:

  • Arsenic exposure is a global concern with potential health implications.
  • Thyroid hormones play a crucial role in regulating metabolism and overall health.
  • Urinary arsenic metabolites are biomarkers of exposure and can indicate different arsenic sources.

Purpose of the Study:

  • To investigate the association between urinary arsenic metabolites and thyroid function biomarkers.
  • To explore potential sex-specific and iodine status-dependent effects of arsenic on thyroid health.

Main Methods:

  • Utilized data from the 2007-2010 National Health and Nutrition Examination Survey (NHANES).
  • Analyzed associations between urinary total arsenic (UAS), arsenobetaine (UAB), dimethylarsinic acid (UDMA), and arsenic adjusted for arsenobetaine (UAAS) with thyroid hormones (TSH, FT4, TT4, FT3, TT3) and thyroglobulin (TGN).
  • Stratified analyses were performed based on sex and iodine status (deficient vs. replete).

Main Results:

  • In iodine-deficient males, UDMA was positively associated with TSH and negatively with TT4.
  • UAAS showed an inverse association with TT4 in both iodine-deficient and iodine-replete females.
  • In iodine-replete females, TSH and TGN increased with decreasing UAB and UAS levels, while TSH was negatively associated with UAB and UAS.
  • In iodine-replete males, UDMA was associated with decreasing FT4 levels.

Conclusions:

  • Urinary arsenic metabolite levels are associated with thyroid function markers in a sex- and iodine status-dependent manner.
  • Dimethylarsinic acid (UDMA) and other arsenic metabolites may influence thyroid hormone levels.
  • Findings suggest a potential role for arsenic exposure in thyroid dysfunction, warranting further investigation.