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Related Experiment Videos

Fatality resulting from cyclizine overdose.

R C Backer1, P McFeeley, N Wohlenberg

  • 1Office of the Medical Investigator for the State of New Mexico, University of New Mexico, School of Medicine, Albuquerque 87106.

Journal of Analytical Toxicology
|September 1, 1989
PubMed
Summary
This summary is machine-generated.

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This case study details a fatal overdose of cyclizine, a common antihistamine. Toxicological tests confirmed a high blood concentration of 80 micrograms/mL, indicating a lethal level of the drug.

Area of Science:

  • Forensic Toxicology
  • Clinical Chemistry

Background:

  • Cyclizine is an over-the-counter antihistamine and antiemetic medication.
  • Overdose fatalities involving cyclizine are rare, making this case significant for toxicological study.

Observation:

  • A fatality was investigated, with preliminary findings suggesting a drug overdose.
  • The deceased individual had a reported history of cyclizine use.

Findings:

  • Toxicological analysis detected a significant blood concentration of cyclizine at 80 micrograms/mL.
  • Gas chromatography/mass spectrometry (GC/MS) was employed for precise quantification of cyclizine.
  • Qualitative analysis of urine and stomach contents further supported the presence of cyclizine.

Implications:

Related Experiment Videos

  • This case highlights the potential for cyclizine toxicity and overdose, even with commonly available medications.
  • Establishing toxicological reference ranges for cyclizine in overdose cases is crucial for forensic investigations.
  • The findings underscore the importance of comprehensive toxicological screening in unexplained fatalities.