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Controlled release from protein particles encapsulated by molecular layer deposition
Siddarth A Vasudevan1, Yaolin Xu, Saurabh Karwal
1Department of Chemical Engineering, Delft University of Technology, The Netherlands. J.R.vanOmmen@tudelft.nl.
Chemical Communications (Cambridge, England)
|July 9, 2015
Summary
Molecular layer deposition (MLD) effectively coats protein particles, significantly reducing their dissolution rate. This coating technology offers a promising method for controlling particle behavior in various applications.
Area of Science:
- Materials Science
- Chemical Engineering
- Biotechnology
Background:
- Controlling the dissolution rate of protein particles is crucial for applications in drug delivery, food science, and biomaterials.
- Traditional methods for modifying particle surfaces can be complex and may affect particle integrity.
Purpose of the Study:
- To investigate the efficacy of Molecular Layer Deposition (MLD) for coating micron-sized protein particles.
- To evaluate the impact of MLD coating cycles on the dissolution characteristics of protein particles.
Main Methods:
- Micron-sized protein particles were coated using Molecular Layer Deposition (MLD) within a fluidized bed reactor.
- Dissolution rates of coated and uncoated protein particles were measured and compared.
Main Results:
- MLD coating significantly reduced the dissolution rate of protein particles.
- The reduction in dissolution rate was directly correlated with an increased number of MLD coating cycles.
- Uncoated protein particles exhibited instantaneous dissolution.
Conclusions:
- MLD is a highly effective technique for creating protective coatings on protein particles.
- The MLD process allows for tunable control over the dissolution properties of protein particles, with potential for tailored applications.
