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Wetting, percolation and morphogenesis in a model tissue system.

G Forgacs1, N S Jaikaria, H L Frisch

  • 1Department of Physics, Clarkson University, Potsdam, New York.

Journal of Theoretical Biology
|October 9, 1989
PubMed
Summary
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Artificial tissues exhibit matrix-driven translocation, where particles move into fibronectin-rich areas. This movement is explained by wetting theory and percolation, offering insights into tissue morphogenesis.

Area of Science:

  • Biophysics
  • Materials Science
  • Developmental Biology

Background:

  • Artificial tissues composed of cells or polystyrene beads in collagen matrices can exhibit directed movement.
  • This phenomenon, termed matrix-driven translocation, involves particle protrusion into fibronectin-containing regions.

Purpose of the Study:

  • To investigate the physical driving forces behind matrix-driven translocation in artificial tissue models.
  • To explore the applicability of wetting and percolation theories to explain tissue morphogenesis.

Main Methods:

  • Constructing artificial tissue models using type I collagen, cells or polystyrene beads, and fibronectin.
  • Analyzing the conditions required for matrix-driven translocation, including heparin-like molecules, particle/collagen concentrations, ionic strength, and pH.

Related Experiment Videos

  • Applying wetting theory and percolation theory to model the observed phenomena.

    • Main Results:

    • Matrix-driven translocation occurs under specific conditions, including the presence of heparin-like molecules and appropriate matrix concentrations.
    • Wetting theory can account for the system's behavior, provided the matrix regions form separate phases at thermodynamic coexistence.
    • Percolation network formation of collagen fibers on cell/bead lattices is a plausible mechanism for phase separation.

    Conclusions:

    • The concerted movement of matrix and particles in artificial tissues can be driven by the spontaneous spreading of immiscible fluid phases.
    • Wetting and percolation concepts provide a physical framework for understanding aspects of tissue morphogenesis.
    • This model system offers insights into the physical principles governing biological tissue development.