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Echocardiographic and Histological Examination of Cardiac Morphology in the Mouse
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Imaging cardiac morphology in hypertrophic cardiomyopathy: recent advances

Nathaniel Reichek1

  • 1From the Research Department and the Cardiac Imaging Program, St. Francis Hospital-the Heart Center and Stony Brook University, New York, USA.

Current Opinion in Cardiology
|July 9, 2015
PubMed

Insights

Cardiac MRI (CMR) reveals new findings in hypertrophic cardiomyopathy (HCM). Advanced CMR techniques help risk-stratify patients and identify novel phenotypes, improving diagnosis and prognosis.

Area of Science:

  • Cardiology
  • Medical Imaging

Background:

  • Hypertrophic cardiomyopathy (HCM) is a primary genetic heart muscle disease.
  • Accurate risk stratification and understanding of HCM phenotypes are crucial for patient management.

Purpose of the Study:

  • To detail novel cardiac magnetic resonance (CMR) findings related to cardiac structure and myocardial composition in HCM.
  • To explore the role of advanced CMR techniques in HCM evaluation.

Main Methods:

  • Quantitative CMR assessment of myocardial fibrosis (replacement and interstitial).
  • Analysis of cardiac structure, including left ventricular hypertrophy (LVH) distribution and severity.
  • Identification of associated abnormalities like myocardial noncompaction and mitral valve apparatus issues.

Main Results:

  • Quantitative CMR assessment of fibrosis aids in risk stratification for adverse outcomes in HCM patients.
  • Global LVH is associated with poorer outcomes, while a spiral hypertrophy pattern suggests a better prognosis.
  • New CMR phenotypes, including myocardial noncompaction and abnormalities in relatives of HCM probands, are identified.

Conclusions:

  • CMR provides valuable structural insights, including hypertrophy and fibrosis patterns, augmenting clinical HCM evaluation.
  • Emerging CMR methods offer potential for detecting myocardial fiber disarray and altered stiffness, enhancing understanding of HCM pathophysiology and outcomes.
Abstract

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