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Gastrulation01:56

Gastrulation

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Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
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Eukaryotic Evolution01:24

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The endosymbiont theory is the most widely accepted theory of eukaryotic evolution; however, its progression is still somewhat debated. According to the nucleus-first hypothesis, the ancestral prokaryote first evolved a membrane to enclose DNA and form the nucleus. Conversely, the mitochondria-first hypothesis suggests that the nucleus was formed after endosymbiosis of mitochondria.
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Zygotic Development And Stem Cell Formation01:10

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The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
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Evolutionary Processes in Microbes01:26

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Microbial evolution occurs rapidly due to short generation times and a variety of genetic processes, including horizontal gene transfer, mutation, recombination, and genetic drift. These mechanisms collectively enable microbes to adapt swiftly to changing environments.Horizontal gene transfer (HGT) allows genes to move between different species and occurs through three main mechanisms: conjugation, transformation, and transduction. Conjugation involves direct cell-to-cell contact for DNA...
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Cleavage and Blastulation01:33

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After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
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Morphogenesis02:19

Morphogenesis

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Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
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Related Experiment Video

Updated: Apr 7, 2026

Creating Avian Forebrain Chimeras to Assess Facial Development
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Snakes: hatching of a model system for Evo-Devo?

Isabel Guerreiro1, Denis Duboule

  • 1Department of Genetics and Evolution, University of Geneva, Switzerland.

The International Journal of Developmental Biology
|July 9, 2015
PubMed
Summary

Evolutionary Developmental Biology (Evo-Devo) research is expanding to include squamates. Snakes offer unique insights into vertebrate development, despite current study limitations.

Area of Science:

  • Evolutionary Developmental Biology (Evo-Devo)
  • Comparative Genomics
  • Vertebrate Development

Background:

  • Evo-Devo research utilizes diverse animal models to understand phenotypic variation from conserved genes.
  • The squamate clade, particularly snakes, is underrepresented in Evo-Devo despite unique morphology and metabolism.
  • Recent genomic and transcriptomic data for squamates provide new tools for biological studies.

Purpose of the Study:

  • To highlight the value of developing snake embryos in assessing vertebrate developmental mechanisms.
  • To discuss the relevance of snakes as Evo-Devo model systems.
  • To identify and address limitations in snake developmental and genetic studies.

Main Methods:

  • Analysis of recent genomic and transcriptomic data from squamates.

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  • Examination of developing snake embryos.
  • Literature review on Evo-Devo methodologies and squamate biology.
  • Main Results:

    • Developing snake embryos offer valuable insights into fundamental vertebrate developmental processes.
    • Squamates present a promising, yet underexplored, model system for Evo-Devo research.
    • Genomic resources are enabling new avenues for studying snake development.

    Conclusions:

    • Snakes are emerging as crucial models for Evo-Devo, bridging gaps in understanding vertebrate development.
    • Overcoming current limitations is key to fully realizing the potential of snakes in Evo-Devo research.
    • Further integration of genomic data and developmental studies will advance the field.