Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

904
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
904
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

1.1K
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
1.1K
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

1.6K
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
1.6K
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

503
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
503
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies01:28

Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies

820
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
820
Pancreas01:19

Pancreas

3.2K
The pancreas, an essential organ in the human body, is a pinkish-gray elongated structure located posterior to the stomach. It extends laterally from the duodenum towards the spleen and is firmly bound to the posterior wall of the abdominal cavity. The organ's surface has a lumpy, lobular texture that gives it a unique appearance.
The broad head of the pancreas lies within the loop formed by the duodenum, while its slender body reaches towards the spleen. The tail of the pancreas is short...
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

What grows in the sink splash zone.

The Journal of hospital infection·2026
Same author

What Do Our Patients Need: More Physiological Understanding or More Psychological Labels?

Gastroenterology·2026
Same author

IS<i>1216</i> drives the evolution of pRUM-like multidrug resistance plasmids in <i>Enterococcus faecium</i>.

Microbial genomics·2025
Same author

Identification and response to a putatively hypervirulent, carbapenem-resistant <i>Klebsiella pneumoniae</i> ST395 hospital outbreak in the UK.

Microbial genomics·2025
Same author

New resistance threat in difficult-to-treat resistance <i>Pseudomonas aeruginosa</i> co-producing AFM and KPC carbapenemases: plasmid dynamic transfer and global phylogeography perspective.

Emerging microbes & infections·2025
Same author

The Kocurious case of Noodlococcus: genomic insights into <i>Kocuria rhizophila</i> from characterisation of a laboratory contaminant.

Microbial genomics·2025

Related Experiment Video

Updated: Apr 7, 2026

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion
06:44

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion

Published on: February 28, 2021

4.7K

Pancreatic pain.

Robert A Moran1, Theodore James, Pankaj Jay Pasricha

  • 1Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

Current Opinion in Gastroenterology
|July 9, 2015
PubMed
Summary

Chronic pancreatitis pain is complex and often undertreated. Understanding the neurobiology of pain and sensitization is key to improving management strategies for this debilitating condition.

Area of Science:

  • Neurogastroenterology
  • Pain Medicine
  • Gastroenterology

Background:

  • Chronic pancreatitis presents with severe pain, significantly impacting patients' socioeconomic status.
  • Previous management approaches were ineffective due to a lack of understanding of underlying pain mechanisms.
  • This review focuses on the neurobiological basis of pain in chronic pancreatitis.

Purpose of the Study:

  • To elucidate the neurobiology of pain and sensitization in chronic pancreatitis.
  • To explain the reasons for the failure of historical pain management paradigms.
  • To propose future directions for effective pain management in chronic pancreatitis.

Main Methods:

  • Review of recent scientific literature on the neurobiology of pain in chronic pancreatitis.

More Related Videos

An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation
06:28

An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation

Published on: October 31, 2025

566
Robotic Lateral Pancreaticojejunostomy for Chronic Pancreatitis
08:10

Robotic Lateral Pancreaticojejunostomy for Chronic Pancreatitis

Published on: December 14, 2019

11.9K

Related Experiment Videos

Last Updated: Apr 7, 2026

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion
06:44

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion

Published on: February 28, 2021

4.7K
An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation
06:28

An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation

Published on: October 31, 2025

566
Robotic Lateral Pancreaticojejunostomy for Chronic Pancreatitis
08:10

Robotic Lateral Pancreaticojejunostomy for Chronic Pancreatitis

Published on: December 14, 2019

11.9K
  • Analysis of advances in assessing pain sensitization in patients.
  • Correlation of neurobiological findings with clinical outcomes.

    • Main Results:

    • Recent research has significantly advanced the understanding of pain neurobiology in chronic pancreatitis.
    • Clinical methods for assessing pain sensitization have improved.
    • Pain sensitization assessment predicts patient response to medical and surgical treatments.

    Conclusions:

    • Pain in chronic pancreatitis is a multifaceted issue requiring a neurobiological approach.
    • Failure to address neurobiological mechanisms leads to ineffective treatment.
    • New insights into pain neurobiology offer promising avenues for improved patient management.