Related Experiment Video
Updated: Apr 7, 2026

In Vivo Confocal Microscopy in the Diagnosis and Management of Dry Eye: A Focus on Imaging Protocols and Interpretation
Published on: November 11, 2025
Orbital Myositis as Both a Presenting and Associated Extraintestinal Sign of Crohn's Disease
Caroline W Vargason1, Louise A Mawn
1Vanderbilt Eye Institute, Vanderbilt University School of Medicine, 2311 Pierce Avenue, Nashville, Tennessee, U.S.A.
Abstract:
Orbital myositis is a rare extraintestinal manifestation of inflammatory bowel disease and has been reported to occur at variable times relative to gastrointestinal symptoms, including years before, concurrently to, and years after the gastrointestinal diagnosis. Here, the authors report 3 cases of Crohn's disease associated orbital myositis, adding to the 18 previously reported cases. The authors describe 2 cases of middle-aged females presenting with orbital myositis during clinical remission of Crohn's disease. The authors also describe the first reported case of orbital myositis-associated Crohn's disease diagnosed prior to any gastrointestinal symptoms in a teenage male presenting with corticosteroid responsive intermittent eyelid swelling. These cases underscore the importance of the Ophthalmic Plastic Surgeon in initiating a thorough systemic workup for cases of orbital inflammatory disease.
Related Concept Videos
Inflammatory Bowel Disease II: Crohn's Disease
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Appendicitis-I: Introduction
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Accessory Structures of the Eye
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...

