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Updated: Apr 7, 2026

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
Published on: August 18, 2020
Cannabis use, schizotypy, and negative priming
Lucy Albertella1, Mike E Le Pelley2, Jan Copeland1
1National Cannabis Prevention and Information Centre, UNSW, Australia.
This study found that higher impulsive nonconformity and psychological distress impact cognitive control in young cannabis users. Younger, frequent cannabis users may face heightened risks for psychosis-related disorders.
Area of Science:
- Neuroscience
- Psychology
- Cannabis Research
Background:
- Adolescent cannabis use is prevalent and raises concerns about cognitive function.
- Schizotypy, a personality trait related to psychosis, may interact with cannabis effects.
- Understanding factors influencing cognitive control in young users is crucial for public health.
Purpose of the Study:
- To investigate the impact of cannabis use frequency, schizotypy, and age on cognitive control.
- To examine the relationship between psychological distress and cognitive control in young cannabis users.
- To identify potential risks associated with early and frequent cannabis consumption.
Main Methods:
- A location-based negative priming task was used to measure cognitive control.
- 124 Australian adolescents and young adults (aged 15-24) who had used cannabis were recruited.
- Data on cannabis use frequency, schizotypy, age, and psychological distress were collected.
Main Results:
- Higher scores on the Impulsive Nonconformity dimension of schizotypy were linked to reduced negative priming.
- Increased psychological distress correlated with greater negative priming.
- A significant age by cannabis use interaction indicated younger, frequent users showed more pronounced effects on cognitive control.
Conclusions:
- Schizotypy and psychological distress significantly influence cognitive control in young cannabis users.
- Younger individuals who frequently use cannabis may be more vulnerable to cognitive impairments.
- Findings suggest a potential elevated risk for psychosis-related disorders in this demographic.
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