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In Vivo Infection with Leishmania amazonensis to Evaluate Parasite Virulence in Mice
Published on: February 20, 2020
Short communication: mucocutaneous leishmaniasis in HIV-related immune reconstitution syndrome
Grace L Lee1, Kenneth L Woods2, Lindsey Clark3
11 Division of Dermatology, Wexner Medical Center, The Ohio State University , Columbus, Ohio.
Abstract:
Immune reconstitution inflammatory syndrome (IRIS) is an immuno-pathologic reaction to quiescent opportunistic microbial pathogens upon restoration of underlying immune defects. Here we report a Honduran patient with HIV/AIDS who developed a facial rash worsening on antiretroviral therapy and increasing CD4 count. Culture and PCR analysis from the skin biopsy identified Leishmania panamensis, which was effectively treated with long-term liposomal amphotericin B. This is the first report of mucocutaneous leishmaniasis (MCL)-associated IRIS due to L. panamensis.
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