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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

2.2K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

1.8K
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
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Other Disorders of Digestive System01:30

Other Disorders of Digestive System

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The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.5K
Gastritis-I: Introduction and Types01:27

Gastritis-I: Introduction and Types

3.4K
Gastritis, defined by the inflammation or irritation of the stomach lining or gastric mucosa, manifests in several distinct forms: acute, chronic, reactive, and a specific subtype known as autoimmune metaplastic atrophic gastritis.
Acute gastritis presents as a sudden inflammation triggered by various stressors to the stomach lining, such as exposure to corrosive agents, local irritants like aspirin and other NSAIDs, alcohol consumption, radiation therapy, physical trauma, severe burns, sepsis,...
3.4K
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

944
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
944

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Related Experiment Video

Updated: Apr 7, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Celiac disease as an autoimmune condition.

Gabriel Samasca1, Genel Sur1, Iulia Lupan2

  • 1Department of Immunology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania ; Children's Emergency Hospital, Cluj-Napoca, Romania.

Central-European Journal of Immunology
|July 9, 2015
PubMed
Summary

Celiac disease, an autoimmune disorder, shows evolving clinical autoimmunity. Research is exploring new targets like specific autoantigens and immune cells for improved celiac disease treatment strategies.

Keywords:
autoimmunity diseasediagnosisresearch direction

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A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
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Area of Science:

  • Immunology
  • Gastroenterology
  • Endocrinology

Background:

  • Autoimmune diseases represent a significant and growing global health concern.
  • Celiac disease serves as a key model for studying autoimmune disease mechanisms.
  • Understanding the evolving clinical autoimmunity in celiac disease is crucial for patient management.

Purpose of the Study:

  • To track recent changes in the clinical autoimmunity associated with celiac disease.
  • To identify and analyze associated autoimmune conditions linked to celiac disease.
  • To explore novel immunological markers and therapeutic targets in celiac disease.

Main Methods:

  • Review of clinical data on celiac disease autoimmunity.
  • Analysis of immune reactivity to autoantigens such as tissue transglutaminase and others.
  • Investigation of emerging research areas including specific cytokines, immune cells, and genetic factors.

Main Results:

  • Celiac disease is associated with a spectrum of autoimmune conditions including type 1 diabetes, thyroid autoimmunity, and systemic lupus erythematosus.
  • Immune responses involve autoantibodies targeting tissue transglutaminase and other autoantigens like actin and zonulin.
  • New research points to the role of interleukin-1, interleukin-2, and specific T cell populations in celiac disease pathogenesis.

Conclusions:

  • The clinical autoimmunity landscape of celiac disease is dynamic and linked to numerous other autoimmune disorders.
  • Identification of specific autoantigens and immune pathways offers potential for targeted therapies.
  • Future research directions focusing on immune cell interactions and pathogenic T cell epitopes may lead to breakthroughs in celiac disease treatment.