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Published on: October 20, 2013
Non-typhoid salmonella septic arthritis in dual living liver transplant recipient: a case report
Kun Moo Choi1, Cheon Soo Park1, Gi-Won Song2
1Department of Surgery, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Korea.
Abstract:
Non-typhoid salmonellosis is an infectious disease caused by Salmonella species other than Salmonella typhi. Although the usual clinical course of non-typhoid salmonellosis is a benign self-limiting gastroenteritis, these bacteria are especially problematic in immunocompromised individuals, including patients with malignancies, human immunodeficiency virus, or diabetes, and those receiving corticosteroids or other immunotherapy agents. In addition to enteric symptoms, Salmonella species give rise to extra-intestinal complications, including self-limiting arthritis, which appears 1 to 3 weeks after the onset of infection and lasts from a few weeks to several months. In some patients, however, this arthritis spears to be chronic in nature. We describe herein a living-donor liver transplant recipient who experienced non-typhoid Salmonella-triggered arthritis in the left hip. The patient recovered uneventfully after 6-month-long antibiotics treatment. Clinicians involved in transplantation should be aware of the possibility that transplant recipients, like other immunocompromised individuals, are at risk of salmonellosis and therefore require careful clinical and microbiological evaluation, with the goals of prevention and early recognition of infection.
Insights
Non-typhoid Salmonella infection can cause joint issues, particularly in immunocompromised patients. A liver transplant recipient successfully recovered from Salmonella-triggered hip arthritis after antibiotic treatment.
Area of Science:
- Infectious Diseases
- Immunology
- Transplantation Medicine
Background:
- Non-typhoid salmonellosis typically causes self-limiting gastroenteritis.
- Immunocompromised individuals are at higher risk for severe non-typhoid Salmonella infections and extra-intestinal complications.
- Salmonella species can lead to arthritis, which may be chronic in some cases.
Observation:
- A living-donor liver transplant recipient developed non-typhoid Salmonella-triggered arthritis in the left hip.
- The patient's condition was successfully treated with a 6-month course of antibiotics.
Findings:
- This case highlights the risk of Salmonella infections, including arthritis, in transplant recipients.
- Early clinical and microbiological evaluation is crucial for prevention and recognition of Salmonella infections in this population.
Implications:
- Transplant recipients require heightened awareness and vigilance for Salmonella infections.
- Prompt diagnosis and treatment are essential for managing Salmonella-induced arthritis in immunocompromised patients.
- This case underscores the importance of considering Salmonella as a potential pathogen in transplant recipients presenting with joint pain.
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