Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

814
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
814
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

348
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
348
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

327
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
327
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

336
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
336
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

321
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
321
Bone Disorders01:29

Bone Disorders

8.1K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
8.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A novel less invasive single port pulsatile ventricular assist device.

JHLT open·2026
Same author

Governing the rise of AI in healthcare: A comparative governance document and implementation implications across five jurisdictions.

Social science & medicine (1982)·2026
Same author

Patterns and determinants of mitogenomic evolution in Bilateria.

Nature communications·2026
Same author

Empowerment-based case management for treatment-resistant schizophrenia: a three-year single case report.

Frontiers in psychiatry·2026
Same author

Functional study and sequence variation of the SrUGT85C2 genes in Stevia rebaudiana.

BMC plant biology·2026
Same author

Design and Synthesis of Trithiophene-Based Donor-Acceptor Covalent Organic Framework for Cocatalyst-Free Photocatalytic Hydrogen Evolution.

ChemSusChem·2026
Same journal

Identification of Genetic Determinants of Weight Loss Efficacy After Roux-en-Y Gastric Bypass Surgery.

Bariatric surgical practice and patient care·2026
Same journal

Ultrasonographic Evaluation of Difficult Airway in Obese Patients: A Prospective Study.

Bariatric surgical practice and patient care·2025
Same journal

Preoperative Weight Loss as a Predictor of Short and Midterm Postoperative Weight Loss in Patients Undergoing Bariatric Surgery.

Bariatric surgical practice and patient care·2023
Same journal

Conversion of Sleeve Gastrectomy to Roux-en-Y Gastric Bypass to Enhance Weight Loss: Single Enterprise Mid-Term Outcomes and Literature Review.

Bariatric surgical practice and patient care·2023
Same journal

Pregnancy and Bariatric Surgery: Significant Variation in Bariatric Surgeons' Practices and Preferences: A National Survey.

Bariatric surgical practice and patient care·2022
Same journal

Bariatric Surgery in Patients with Existing Ostomy: A Preliminary Feasibility Study.

Bariatric surgical practice and patient care·2022
See all related articles

Related Experiment Video

Updated: Apr 7, 2026

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice
10:05

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice

Published on: March 20, 2017

12.9K

Does Age Influence Bariatric Surgery Outcomes?

Raquel Gonzalez-Heredia1, Neil Patel1, Lisa Sanchez-Johnsen1

  • 1Division of General, Minimally Invasive, and Robotic Surgery, University of Illinois at Chicago College of Medicine , Chicago, Illinois.

Bariatric Surgical Practice and Patient Care
|July 9, 2015
PubMed
Summary
This summary is machine-generated.

Age is not a limiting factor for bariatric surgery. This study found that older patients experienced similar or fewer complications and comparable weight loss outcomes after bariatric surgery compared to younger patients.

More Related Videos

Sleeve Gastrectomy in Mice using Surgical Clips
05:16

Sleeve Gastrectomy in Mice using Surgical Clips

Published on: November 14, 2020

7.6K
Roux-en-Y Gastric Bypass Operation in Rats
07:37

Roux-en-Y Gastric Bypass Operation in Rats

Published on: June 11, 2012

24.5K

Related Experiment Videos

Last Updated: Apr 7, 2026

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice
10:05

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice

Published on: March 20, 2017

12.9K
Sleeve Gastrectomy in Mice using Surgical Clips
05:16

Sleeve Gastrectomy in Mice using Surgical Clips

Published on: November 14, 2020

7.6K
Roux-en-Y Gastric Bypass Operation in Rats
07:37

Roux-en-Y Gastric Bypass Operation in Rats

Published on: June 11, 2012

24.5K

Area of Science:

  • Geriatric Medicine
  • Surgical Innovation
  • Obesity Research

Background:

  • Bariatric surgery is an effective treatment for severe obesity.
  • Patient selection criteria for bariatric surgery, particularly regarding age, require ongoing evaluation.

Purpose of the Study:

  • To assess if age should be a criterion for bariatric surgery selection.
  • To evaluate comorbidities, complications, and outcomes in older bariatric surgery patients.

Main Methods:

  • Retrospective analysis of 750 patients undergoing sleeve gastrectomy or Roux-en-Y gastric bypass.
  • Patients categorized into three age groups: <55, 55–64, and ≥65 years.
  • Comparison of demographics, comorbidities, complications, and weight loss outcomes across age groups.

Main Results:

  • Significant differences in presurgical comorbidities were observed across age groups.
  • Fewer complications (leaks or conversions) were noted in patients over 55.
  • No significant differences in length of stay or percentage excess weight loss at 6, 12, and 24 months were found between age groups.

Conclusions:

  • Age alone should not be a primary factor in selecting patients for bariatric surgery.
  • Minimally invasive bariatric procedures appear safe and effective in older adult populations.
  • Further research may explore specific age-related risk stratification.