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Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
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Association between Experimental Bacterial Meningitis and Periapical Lesion
Tatiana Barichello1, Soraia Netto1, Renan Antonio Ceretta1
1Laboratório de Microbiologia Experimental, Programa de Pós-Graduação em Ciências da Saúde, Unidade Acadêmica de Ciências da Saúde, Universidade do Extremo Sul Catarinense , 888806-000, Criciúma, SC, Brazil .
Journal of Clinical and Diagnostic Research : JCDR
|July 9, 2015
Summary
Bacterial meningitis in rats led to increased periodontal ligament space and impaired habituation memory. This suggests a link between pneumococcal meningitis and cognitive deficits, particularly in periapical lesion development.
Area of Science:
- Neuroscience
- Infectious Diseases
- Oral Health
Background:
- Bacterial meningitis causes high mortality in Africa.
- Periodontal diseases and dental caries are highly prevalent.
- The link between meningitis and periapical lesions is unexplored.
Purpose of the Study:
- To investigate the impact of pneumococcal meningitis on periapical lesion development.
- To evaluate cognitive function in rats with meningitis and periapical lesions.
Main Methods:
- Wistar rats were divided into control and meningitis groups, with and without induced periapical lesions.
- Periapical lesions were created by exposing dental pulp.
- Behavioral tasks and periodontal ligament size were assessed.
Main Results:
- Meningitis with periapical lesions increased periodontal ligament space by 61% compared to controls.
- No significant differences in open-field task performance were observed between groups.
- Habituation memory impairment was noted in meningitis and periapical lesion groups.
Conclusions:
- Bacterial meningitis may influence periapical lesion development.
- Meningitis and periapical lesions are associated with cognitive impairment, specifically habituation memory deficits.
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