Related Experiment Video
Updated: Apr 7, 2026
05:18
Author Spotlight: Ultrasound-Guided Needle Release Combined with Corticosteroid Injection for the Treatment of Supinator Syndrome
Published on: May 26, 2023
2.0K
Multiple Adverse Effects of Systemic Corticosteroids: A Case Report
Divya Satyanarayanasetty1, Kavitha Pawar2, Pratibha Nadig3
1Post Graduate, Department of Pharmacology, Vydehi Institute of Medical Sciences & Research Centre , Bangalore, India .
Journal of Clinical and Diagnostic Research : JCDR
|July 9, 2015
Summary
Self-medication with corticosteroids can lead to serious health issues like osteoporosis, cataracts, and hormonal suppression. This case highlights the severe adverse effects of long-term glucocorticoid misuse.
Area of Science:
- Endocrinology
- Ophthalmology
- Rheumatology
Background:
- Corticosteroids are widely used for various medical conditions.
- Long-term administration is associated with significant adverse effects, including osteoporosis and cataracts.
- Individual adverse effects have been extensively reported.
Observation:
- A 55-year-old female presented with acute exacerbation of bronchial asthma.
- She reported self-medication with systemic glucocorticoids.
- This self-medication led to multiple adverse effects.
Findings:
- The patient developed bilateral cataracts.
- Osteoporosis was diagnosed.
- Diabetes mellitus was identified.
- Hypothalamic-pituitary-adrenal (HPA) axis suppression was confirmed.
Implications:
- Highlights the risks of self-medication with corticosteroids.
- Underscores the importance of medical supervision for glucocorticoid therapy.
- Demonstrates the potential for multiple, severe adverse effects from systemic glucocorticoid misuse.
Related Concept Videos
01:27Adrenal Gland Disorders
3.9K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
3.9K
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
2.0K
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
2.0K
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
657
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
657
01:29Hypersensitivity Reactions: Delayed Hypersensitivity Reactions
217
Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
217
01:01Hypersensitivity Reactions: Cytolytic Reactions
135
Type II hypersensitivity involves IgG and IgM antibodies targeting cell surface antigens, leading to cell destruction. This can occur through complement activation, antibody-dependent cell-mediated cytotoxicity (ADCC), or acting as opsonins for phagocytosis. When excessive, these reactions cause significant tissue damage.Drug-induced hemolytic anemia is a common example, where drugs like penicillin or cephalosporins bind to red blood cells, forming drug-protein complexes. These complexes...
135
01:26COPD: Management Using Bronchodilators and Corticosteroids
1.2K
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
1.2K