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MMP-3 can distinguish isolated PMR from PMR with GCA: A retrospective study regarding PMR and GCA in Japan

Shoichi Fukui1,2, Takahiro Nunokawa3, Satomi Kobayashi1

  • 1a Department of Rheumatology , Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital , Tokyo , Japan.

Modern Rheumatology
|July 10, 2015
PubMed
Abstract

Insights

Low matrix metalloproteinase-3 (MMP-3) levels predict polymyalgia rheumatica with giant cell arteritis (GCA). Female gender and low creatinine predict relapse in isolated PMR patients.

Area of Science:

  • Rheumatology
  • Clinical Immunology

Background:

  • Polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) are inflammatory conditions.
  • Distinguishing isolated PMR from PMR with GCA is clinically important.
  • Predicting relapse and corticosteroid discontinuation in isolated PMR aids patient management.

Purpose of the Study:

  • Identify clinical features differentiating isolated PMR from PMR with GCA at diagnosis.
  • Determine predictors of relapse and corticosteroid discontinuation in isolated PMR.

Main Methods:

  • Retrospective study of 115 isolated PMR patients and 29 GCA patients.
  • Comparative analysis between isolated PMR, GCA, and PMR with GCA groups.
  • Logistic regression used to identify relapse and corticosteroid discontinuation predictors in isolated PMR.

Main Results:

  • Matrix metalloproteinase-3 (MMP-3) levels differed significantly between groups: isolated PMR (230.5 ± 201.5 ng/mL), GCA (80.5 ± 47.5 ng/mL), and PMR with GCA (96.8 ± 54.8 ng/mL).
  • Low MMP-3 levels were a positive predictor for PMR with GCA.
  • In isolated PMR, female gender (OR 2.73) and creatinine < 50 μmol/L (OR 2.48) predicted relapse.

Conclusions:

  • Low MMP-3 levels are a strong indicator of PMR with GCA.
  • Female gender and low creatinine are significant predictors of relapse in isolated PMR.
  • These findings aid in differentiating PMR subtypes and predicting disease course.
Keywords:
Giant cell arteritisMMP-3Polymyalgia rheumaticaPredictorsPrognosis

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