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[Posterior reversible encephalopathy: beyond the original description].

Josué M Avecillas-Chasín1, Jordi A Matías-Guiu, Luis Bautista-Balbás

  • 1Hospital Clinico San Carlos, 28035 Madrid, Espana.

Revista De Neurologia
|July 10, 2015
PubMed
Summary

Posterior reversible encephalopathy (PRE) is a neurological condition often linked to specific triggers. While typically reversible with prompt treatment, its definition may need re-evaluation due to atypical presentations.

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Area of Science:

  • Neurology
  • Radiology
  • Pathophysiology

Context:

  • Posterior reversible encephalopathy (PRE) presents with headache, visual disturbances, and seizures.
  • Characterized by reversible vasogenic edema in neuroimaging.
  • Diagnosis relies heavily on magnetic resonance imaging due to nonspecific clinical symptoms.

Purpose:

  • Review the pathophysiology of Posterior Reversible Encephalopathy (PRE).
  • Examine the associations of PRE as described in medical literature.
  • Address the need for redefinition of PRE given atypical cases and new triggers.

Summary:

  • PRE involves clinical and radiological manifestations, not strictly a syndrome.
  • Common triggers include hypertensive crisis, eclampsia, and certain medications.
  • Despite rare irreversible cases, the concept of reversibility is key, as lesions often resolve with control of the underlying condition.

Impact:

  • Highlights the importance of MRI in diagnosing PRE.
  • Underscores the evolving understanding of PRE triggers and presentations.
  • Suggests maintaining the reversibility concept in the definition of PRE for accurate clinical management.