Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Kidney Structure01:45

Kidney Structure

77.0K
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
77.0K
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

637
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
637
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

719
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
719
External Anatomy of the Kidney01:21

External Anatomy of the Kidney

4.9K
The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
4.9K
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

817
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
817
Internal Anatomy of the Kidney01:12

Internal Anatomy of the Kidney

9.3K
The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
9.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sequential therapeutic approach for the management of osteoporosis in people with chronic kidney disease.

Nature reviews. Nephrology·2026
Same author

High Prevalence of Secondary Hyperparathyroidism Prior to Kidney Transplantation in Brazil: A Perfect Storm for Adverse Graft Outcomes.

Kidney360·2026
Same author

Time-Lapse HR-pQCT: an in Vivo Imaging-Based Assessment of Bone Remodeling Dynamics.

Current osteoporosis reports·2026
Same author

Difference of Admission Neutrophil Gelatinase-Associated Lipocalin Concentration Between Patients Developing and Not Developing Acute Kidney Injury or Need for Acute Dialysis: An Ancillary Individual-Study Data Meta-Analysis (INDICATE-AKI).

Kidney medicine·2026
Same author

Cassandra's Cortex: The False Reassurance of a Normal T Score in CKD.

Journal of the American Society of Nephrology : JASN·2026
Same author

Osteoporosis and CKD-Metabolic Bone Disease Under the Same Umbrella: Insights From a Joint Scientific Symposium.

Kidney international reports·2026
Same journal

Family matters? A Systematic review of interventions addressing family-level mechanisms in the treatment of childhood and adolescent obesity.

Reviews in endocrine & metabolic disorders·2026
Same journal

What is measured and what is estimated in body composition? A clarification framework for terminology and interpretation.

Reviews in endocrine & metabolic disorders·2026
Same journal

Unveiling the role of aldosterone in metabolic dysfunction-associated steatotic liver disease.

Reviews in endocrine & metabolic disorders·2026
Same journal

Prenatal and postnatal maternal obesity and their associations with child nutrition and weight outcomes: A systematic review.

Reviews in endocrine & metabolic disorders·2026
Same journal

Correction: Overcoming the barriers in the screening, diagnosis, and follow-up of patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH).

Reviews in endocrine & metabolic disorders·2026
Same journal

An elusive link between blood measures of advanced glycation end products and their receptors and cognitive impairment syndromes in people with diabetes: A scoping review.

Reviews in endocrine & metabolic disorders·2026
See all related articles

Related Experiment Video

Updated: Apr 7, 2026

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis
04:37

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis

Published on: April 25, 2025

1.8K

Bone kidney interactions.

Thomas L Nickolas1, Sophie A Jamal

  • 1Department of Medicine, Nephrology, Columbia University Medical Center, 622 West 168th Street, PH4-124, New York, NY, 10032, USA.

Reviews in Endocrine & Metabolic Disorders
|July 10, 2015
PubMed
Summary
This summary is machine-generated.

Chronic kidney disease mineral bone disorder (CKD-MBD) involves bone and kidney disease. Recent findings show bone actively influences CKD-MBD and other organs early in kidney disease progression.

More Related Videos

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

826
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

1.9K

Related Experiment Videos

Last Updated: Apr 7, 2026

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis
04:37

Unilateral Ureteral Obstruction Model for Investigating Kidney Interstitial Fibrosis

Published on: April 25, 2025

1.8K
Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

826
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

1.9K

Area of Science:

  • Nephrology
  • Orthopedics
  • Endocrinology

Background:

  • Bone and kidney disease frequently coexist, a condition termed chronic kidney disease mineral bone disorder (CKD-MBD).
  • Historically, bone was considered a passive victim of CKD-MBD, developing secondary to disordered mineral metabolism caused by kidney disease.
  • Emerging evidence suggests a more complex interplay, with bone potentially playing an active role in the pathogenesis of CKD-MBD.

Purpose of the Study:

  • To review the epidemiology of fractures in patients with chronic kidney disease (CKD).
  • To discuss the utility of imaging and mineral metabolism markers in assessing fracture risk within CKD.
  • To explore the evolving understanding of bone's active role in CKD-MBD, including its early onset and influence on other organ systems.

Main Methods:

  • Review of epidemiological data on fractures in CKD patients.
  • Analysis of the role of imaging modalities in fracture risk assessment.
  • Evaluation of mineral metabolism markers for predicting fracture risk.
  • Synthesis of recent research on the pathophysiology of CKD-MBD, focusing on bone's signaling pathways.

Main Results:

  • Fractures are a significant concern in the CKD population.
  • Imaging and biochemical markers provide valuable insights into fracture risk.
  • Evidence indicates CKD-MBD develops early in CKD progression.
  • Bone actively participates in CKD-MBD through novel molecular secretions and signaling pathways, influencing systemic health.

Conclusions:

  • CKD-MBD is an early complication of CKD, not merely a consequence of long-term kidney dysfunction.
  • Bone is an active endocrine organ that influences systemic metabolism and disease progression in CKD.
  • A paradigm shift is needed to view CKD-MBD as a dynamic interaction between bone and kidney, impacting multiple organ systems.