Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Codon evolution and conservation of the reading phase in genetic code translation.

J C Tohá1, R Donoso, M Estay

  • 1Departmento De Fisica Facultad de Ciencias Fisicas y Matemáticas Universidad de Chile, Santiago.

Medical Hypotheses
|December 1, 1989
PubMed
Summary

This study explores the evolution of genetic codes, proposing models where codon size and information carriers change. It discusses how this optimizes the genetic system

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Characterization and risk of fracture in Chile's adult population. A new look at ENS 2009-2010].

Acta ortopedica mexicana·2021
Same author

[Long-term results of lasik refractive error correction after penetrating keratoplasty in patients with keratoconus].

Archivos de la Sociedad Espanola de Oftalmologia·2015
Same author

Comparative study of keratoconus between Anwar's deep anterior lamellar keratoplasty versus converted penetrating keratoplasty.

Archivos de la Sociedad Espanola de Oftalmologia·2015
Same author

Ab initio molecular dynamics study of small alkali metal clusters.

The journal of physical chemistry. A·2014
Same author

[Evaluation of refractive prognosis factors in myopic LASIK].

Archivos de la Sociedad Espanola de Oftalmologia·2005
Same author

[Emmetropization at cataract surgery. Looking for the best IOL power calculation formula according to the eye length].

Archivos de la Sociedad Espanola de Oftalmologia·2003

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Origin of Life Studies

Background:

  • The genetic code, based on four nucleotides, evolved from simple to complex structures.
  • Increasing codon size (monomers to dimers to triplets) presents challenges in genetic message readability.
  • Maintaining an optimized system during code evolution is crucial for biological function.

Purpose of the Study:

  • To propose and analyze models for the optimized evolution of the genetic code.
  • To investigate mechanisms that overcome potential chaos in genetic message reading during code expansion.
  • To explore how the genetic system's 'hardware' is maintained throughout its evolutionary development.

Main Methods:

  • Theoretical modeling of codon evolution, including changes in size and information-carrying molecules.

Related Experiment Videos

  • Analysis of two distinct hypotheses for genetic code development.
  • Discussion of the probability and plausibility of proposed evolutionary pathways.

    • Main Results:

    • A proposed model suggests simultaneous codon size increase and alternation of information-carrying molecules (nucleotides/peptides) to maintain code integrity.
    • This model involves a sequential reading of monomers, dimers, and triplets.
    • An alternative hypothesis proposes direct generation of trinucleotide codons after a sufficient number of amino acids are produced.

    Conclusions:

    • Both proposed hypotheses offer plausible, albeit low-probability, scenarios for optimized genetic code evolution.
    • The study highlights the importance of maintaining an optimized 'hardware' for the genetic system.
    • Further research is needed to validate these evolutionary models of the genetic code.