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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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  9. Predictive And Prognostic Markers
  11. Dual Prognostic Significance Of Tumour-associated Macrophages In Human Pancreatic Adenocarcinoma Treated Or Untreated With Chemotherapy.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Dual Prognostic Significance Of Tumour-associated Macrophages In Human Pancreatic Adenocarcinoma Treated Or Untreated With Chemotherapy.

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Dual prognostic significance of tumour-associated macrophages in human pancreatic adenocarcinoma treated or untreated with chemotherapy.

Giuseppe Di Caro1, Nina Cortese1, Giovanni Francesco Castino1

  • 1Department of Immunology and Inflammation, Humanitas Clinical and Research Center, Rozzano, Italy.

Gut
|July 10, 2015

View abstract on PubMed

Summary
This summary is machine-generated.

Tumour-associated macrophages (TAMs) influence pancreatic cancer prognosis and chemotherapy response. Chemotherapy re-educates TAMs to inhibit tumour growth, suggesting TAMs can predict treatment success.

Keywords:
CHEMOTHERAPYIMMUNOHISTOCHEMISTRYIMMUNOREGULATIONMACROPHAGES

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Area of Science:

  • Oncology
  • Immunology
  • Cancer Biology

Background:

  • Tumour-associated macrophages (TAMs) are key players in tumour progression and therapy modulation.
  • Targeting TAMs presents a promising strategy for human cancer treatment.

Purpose of the Study:

  • To investigate the prognostic relevance of TAMs in pancreatic ductal adenocarcinoma (PDAC).
  • To assess the impact of chemotherapy (CTX) on TAMs and their role in treatment response.

Main Methods:

  • Retrospective cohort study of 110 PDAC patients.
  • Assessed CD68-TAM density at the tumour-stroma interface.
  • In vitro experiments to study TAM-chemotherapy interactions.

Main Results:

  • TAMs in PDAC showed an immunoregulatory profile (CD206+, CD163+, IL-10+).
PANCREATIC CANCER
  • High TAM density correlated with worse prognosis but chemotherapy mitigated this effect.
  • Chemotherapy (gemcitabine) induced a tumoricidal phenotype in macrophages in vitro.
  • Neoadjuvant chemotherapy decreased CD206+ and IL-10+ TAMs in PDAC patients.

    • Conclusions:

    • TAMs are critical determinants of prognostic response to chemotherapy in PDAC.
    • Chemotherapy directly re-educates TAMs to restrain tumour progression.
    • Quantifying TAMs may help select patients for chemotherapy and guide novel therapeutic strategies.