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Related Concept Videos

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
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Functions of Thyroid Hormones01:18

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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
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Ischemic Heart Disease: Overview01:17

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Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
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Regulation of Stroke Volume01:27

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The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
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Cardiac Output II: Effect of Stroke Volume on Cardiac Output01:22

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Cardiac output (CO), the amount of blood the heart pumps per minute, is a parameter in cardiovascular physiology determined by stroke volume and heart rate. Stroke volume, the amount of blood pushed from one of the ventricles per heartbeat, is influenced by preload, afterload, and contractility.
Preload
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Related Experiment Video

Updated: Apr 7, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
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Thyroid hormones and functional outcomes after ischemic stroke.

Lena M O'Keefe1, Sarah E Conway2, Alexandra Czap1

  • 1Department of Neuroscience, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 USA.

Thyroid Research
|July 10, 2015
PubMed
Summary
This summary is machine-generated.

Low T3 thyroid hormone levels after ischemic stroke correlate with worse outcomes, but this link weakens after accounting for other factors like age and sex. Further research is needed on thyroid hormones and stroke recovery.

Keywords:
Ischemic strokeStroke outcomesThyroid hormones

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Area of Science:

  • Endocrinology
  • Neurology
  • Clinical Medicine

Background:

  • Stroke is a leading cause of death and disability in the US.
  • Low triiodothyronine (T3) levels post-stroke are linked to severity and poor outcomes.
  • Contradictory data exists on thyroid-stimulating hormone (TSH) and stroke outcomes.

Purpose of the Study:

  • To investigate the role of TSH in stroke outcomes.
  • To examine the relationship between TSH, T3, T4, and stroke prognosis.
  • To clarify the complex interplay of thyroid hormones in acute ischemic stroke.

Main Methods:

  • Blood samples collected 24±6 hours post-stroke from patients with confirmed ischemic stroke.
  • Serum levels of TSH, free T3, and free T4 were measured.
  • Functional outcomes assessed at discharge, 3, and 12 months using modified Rankin Scale and Barthel Index.

Main Results:

  • Lower free T3 levels showed an association with worse prognosis at discharge and 3/12 months.
  • This association between free T3 and outcomes did not persist after multivariate analysis.
  • Thyroid hormone associations with stroke outcomes may be influenced by factors like sex, age, and stroke etiology.

Conclusions:

  • Initial associations between low free T3 and poorer stroke outcomes diminished after adjusting for covariates.
  • Thyroid hormones exhibit a complex relationship with ischemic stroke and recovery.
  • Larger investigations are warranted to fully understand thyroid hormone roles in stroke.