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Metronidazole encephalopathy: Uncommon reaction to a common drug

Subramanian Senthilkumaran1, Sweni Shah2, Namasivayam Balamurugan3

  • 1Department of Emergency and Critical Care, Sri Gokulam Hospitals and Research Institute, Salem, India.

International Journal of Critical Illness and Injury Science
|July 10, 2015
PubMed

Insights

Metronidazole can cause encephalopathy, a rare but reversible condition. Recovery is rapid after stopping the drug, especially with lower cumulative doses.

Area of Science:

  • Neurology
  • Pharmacology
  • Toxicology

Background:

  • Metronidazole is a widely used antibiotic.
  • Neurological adverse events are rare but serious complications of metronidazole therapy.

Observation:

  • A case of metronidazole-induced encephalopathy is presented.
  • Literature review on this rare adverse event was conducted.

Findings:

  • Encephalopathy associated with metronidazole is uncommon.
  • The condition is dose-dependent and potentially reversible.
  • Most patients recover rapidly after discontinuing metronidazole.

Implications:

  • Awareness of metronidazole-induced encephalopathy is crucial for clinicians.
  • Early recognition and discontinuation of metronidazole can lead to rapid recovery.
  • Further research into the mechanisms and risk factors is warranted.
Keywords:
Adverse effectencephalopathymetronidazoletoddy

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