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A Case of Persistent Helicobacter pylori Infection Occurring with Anti-IgE Immunosuppression

Daniel Zandman1, William Hahn1, Steven Moss1

  • 1Division of Gastroenterology, Department of Internal Medicine, Rhode Island Hospital, The Warren Alpert School of Medicine of Brown University, Providence, RI.

ACG Case Reports Journal
|July 10, 2015
PubMed

The increasingly widespread use of novel immunosuppressive drugs may lead to unexpected infectious complications. We report a case of persistent Helicobacter pylori (H. pylori) infection that failed to respond to antimicrobial therapy in a patient receiving omalizumab (Xolair™, Genentech USA Inc., San Francisco, CA and Novartis Pharmaceuticals, Basel, Switzerland), an anti-IgE monoclonal antibody approved by the FDA for treatment of severe persistent asthma. To our knowledge, this is the first case report linking an immunosuppressive regimen containing anti-IgE biologic therapy to persistent H. pylori infection.

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