Aspirin-Induced Acute Liver Injury

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Janese Laster1, Rohit Satoskar2

  • 1Department of Internal Medicine, Georgetown University Hospital, Washington, DC.

ACG Case Reports Journal
|July 10, 2015
PubMed

Insights

High-dose aspirin, while generally safe for adults, can cause acute liver injury. This case report highlights potential hepatotoxicity, emphasizing careful monitoring during high-dose aspirin therapy.

Area of Science:

  • Pharmacology
  • Hepatology
  • Clinical Medicine

Background:

  • Aspirin (acetylsalicylic acid) is widely used for its anti-inflammatory and analgesic properties.
  • While its safety profile in adults is generally favorable, known associations exist with Reye syndrome in children.
  • Hepatotoxicity is not a commonly recognized side effect in adult aspirin use.

Observation:

  • A 41-year-old female patient presented with pericarditis.
  • The patient was treated with high-dose aspirin for her condition.
  • Following treatment initiation, she developed acute liver injury, evidenced by elevated liver enzymes and right upper quadrant pain.

Findings:

  • Discontinuation of high-dose aspirin led to the resolution of liver enzyme elevation.
  • Symptoms of right upper quadrant pain also resolved after aspirin cessation.
  • This clinical course strongly suggests a causal link between high-dose aspirin and the observed acute liver injury.

Implications:

  • High-dose aspirin should be recognized as a potential hepatotoxic agent in adult patients.
  • Clinicians should consider monitoring liver function in patients receiving prolonged or high-dose aspirin therapy.
  • Further research may be warranted to elucidate the mechanisms of aspirin-induced hepatotoxicity.

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