Persistent Singultus: Addressing Complexity With Simplicity
Related Experiment Video
Updated: Apr 7, 2026

Development of a Uterosacral Ligament Suspension Rat Model
Published on: August 17, 2022
1Department of Internal Medicine, University of South Florida Morsani School of Medicine, Tampa, FL.
Abstract:
The hiccup reflex arc involving the brainstem, phrenic and vagus nerves, and the sympathetic chain is associated with singultus. There are many possible organic, psychogenic, idiopathic, and iatrogenic instigators. We describe a case of singultus in a 69-year-old man secondary to his CPAP mask, with resolution after he stopped using the mask. Our case establishes that CPAP may be a cause of iatrogenic aerophagia leading to gastric distention, singultus, and emesis and highlights the importance of a complete history.
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