Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

28.6K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
28.6K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

6.3K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
6.3K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

4.1K
4.1K
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

3.5K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
3.5K
iPS Cell Differentiation01:22

iPS Cell Differentiation

3.3K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.3K
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

6.0K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
6.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Implementing proximity care for people with multiple sclerosis in Italy: the bottom-up approach of the StayHome project.

Journal of neurology·2025
Same author

Methylation Mesa define functional regulatory elements for targeted gene activation.

Research square·2024
Same author

Pregnancy effect on disease activity in women with multiple sclerosis treated with cladribine.

Journal of neurology·2024
Same author

Comparative effectiveness and cost-effectiveness of natalizumab and fingolimod in rapidly evolving severe relapsing-remitting multiple sclerosis in the United Kingdom.

Journal of medical economics·2023
Same author

Sexual dysfunction in multiple sclerosis: The impact of different MSISQ-19 cut-offs on prevalence and associated risk factors.

Multiple sclerosis and related disorders·2023
Same author

Do patients' and referral centers' characteristics influence multiple sclerosis phenotypes? Results from the Italian multiple sclerosis and related disorders register.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2022

Related Experiment Video

Updated: Apr 7, 2026

Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells
13:58

Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells

Published on: July 29, 2015

16.2K

Multiple sclerosis: getting personal with induced pluripotent stem cells.

A Di Ruscio1, F Patti2, R S Welner1

  • 11] Department of Medicine, Harvard Medical School, Boston, MA, USA [2] Harvard Stem Cell Institute, Cambridge, MA, USA.

Cell Death & Disease
|July 10, 2015
PubMed
Summary
This summary is machine-generated.

Induced pluripotent stem (iPS) cells offer a new way to study neurodegenerative diseases like multiple sclerosis (MS). These patient-specific cells can advance cell therapies and drug discovery for MS.

More Related Videos

Author Spotlight: Advancements in iPSCs and Genetic Disease Research
06:24

Author Spotlight: Advancements in iPSCs and Genetic Disease Research

Published on: October 20, 2023

2.0K
Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies
12:13

Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies

Published on: July 11, 2019

7.7K

Related Experiment Videos

Last Updated: Apr 7, 2026

Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells
13:58

Derivation of Adult Human Fibroblasts and their Direct Conversion into Expandable Neural Progenitor Cells

Published on: July 29, 2015

16.2K
Author Spotlight: Advancements in iPSCs and Genetic Disease Research
06:24

Author Spotlight: Advancements in iPSCs and Genetic Disease Research

Published on: October 20, 2023

2.0K
Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies
12:13

Generation of Induced Neural Stem Cells from Peripheral Mononuclear Cells and Differentiation Toward Dopaminergic Neuron Precursors for Transplantation Studies

Published on: July 11, 2019

7.7K

Area of Science:

  • Biomedical research
  • Stem cell biology
  • Neuroscience

Background:

  • Human induced pluripotent stem (iPS) cells are derived from lineage-restricted cells.
  • Patient-derived iPS cells preserve donor genetic background, enabling studies in neurodegenerative diseases.
  • iPS cells provide an unlimited source of patient-specific, disease-relevant cells.

Purpose of the Study:

  • To review the potential impact of iPS cell-derived models in multiple sclerosis (MS) research.
  • To highlight current challenges and future prospects for MS therapeutic development using iPS cells.

Main Methods:

  • Review of existing literature on iPS cell applications in neurodegenerative disease research.
  • Focus on the utility of iPS cell-derived models for understanding MS.
  • Discussion of challenges and future directions in the field.

Main Results:

  • iPS cells are a valuable tool for developing patient-specific cell therapies and research models.
  • Patient-derived iPS cells facilitate the study of the human genetics of neurodegenerative diseases.
  • iPS cells hold promise for understanding disease mechanisms, identifying drug targets, and developing phenotypic screens.

Conclusions:

  • iPS cell-derived models have significant potential to advance multiple sclerosis research.
  • Further research and overcoming current challenges are crucial for developing novel therapeutic treatments for MS patients.