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Testosterone Replacement in Androgen-Deficient Men With Ejaculatory Dysfunction: A Randomized Controlled Trial.

Darius A Paduch1, Paula K Polzer1, Xiao Ni1

  • 1Department of Urology (D.A.P.), Weill Cornell Medical College, New York, New York 10065; Lilly Research Laboratories (P.K.P., X.N.), Eli Lilly and Company, Indianapolis, Indiana 46285; and Section on Men's Health, Aging, and Metabolism (S.B.), Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.

The Journal of Clinical Endocrinology and Metabolism
|July 10, 2015
PubMed
Summary
This summary is machine-generated.

Testosterone replacement therapy did not significantly improve ejaculatory dysfunction (EjD) in men with low T levels. This randomized controlled trial found no statistically significant difference compared to placebo for EjD symptoms.

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Area of Science:

  • Endocrinology
  • Men's Health
  • Sexual Medicine

Background:

  • Low testosterone levels are linked to ejaculatory dysfunction (EjD).
  • Previous studies were cross-sectional, lacking randomized controlled trial (RCT) data on testosterone replacement efficacy for EjD.

Purpose of the Study:

  • To assess the effectiveness of testosterone replacement therapy in improving EjD among androgen-deficient men.

Main Methods:

  • A 16-week, multicenter, double-blind, randomized, placebo-controlled trial.
  • Participants included 76 men with EjD symptoms and low total testosterone levels (<300 ng/dL).
  • Interventions involved daily application of 60 mg testosterone solution 2% or placebo to the axillae.

Main Results:

  • Testosterone therapy showed a modest improvement in the MSHQ-EjD-SF score (+3.1) versus placebo (+2.5), but this was not statistically significant (P = .596).
  • No significant differences were observed in secondary outcomes, including ejaculate volume or sexual satisfaction.
  • Adverse event frequencies were similar between the testosterone and placebo groups.

Conclusions:

  • Testosterone replacement therapy did not demonstrate a significant benefit for ejaculatory dysfunction in androgen-deficient men.
  • Further research may be needed to identify specific patient subgroups who might benefit from testosterone therapy for EjD.