Related Experiment Video
Updated: Apr 7, 2026
Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
Published on: April 7, 2023
Progress of Diabetic Severity and Risk of Dementia
Wei-Che Chiu1, Wen-Chao Ho1, Ding-Lieh Liao1
1Institute of Occupational Medicine and Industrial Hygiene (W.-C.C., D.-L.L., P.-C.C.), and Department of Public Health (P.-C.C.), College of Public Health, National Taiwan University, Taipei 10055, Taiwan; Department of Psychiatry (W.-C.C., Y.-P.S.), Cathay General Hospital, Taipei 10630, Taiwan; School of Medicine (W.-C.C., Y.-P.S.), Fu Jen Catholic University, Taipei 24205, Taiwan; Department of Public Health (W.-C.H., M.-H.L.), China Medical University, Taichung 40402, Taiwan; Department of Addiction Psychiatry (D.-L.L.), Bali Psychiatric Center, New Taipei City 24936, Taiwan; Department of Psychiatry (C.-C.C.), Taipei City Psychiatric Center, Taipei City Hospital, 11080 Taipei, Taiwan; Department of Psychiatry (C.-C.C.), School of Medicine, Taipei Medical University, 110 Taipei, Taiwan; and Department of Environmental and Occupational Medicine (P.-C.C.), National Taiwan University College of Medicine and Hospital, Taipei 10051, Taiwan.
Context:
Diabetes is a risk factor for dementia, but the effects of diabetic severity on dementia are unclear.
Objective:
The purpose of this study was to investigate the association between the severity and progress of diabetes and the risk of dementia.
Design And Setting:
We conducted a 12-year population-based cohort study of new-onset diabetic patients from the Taiwan National Health Insurance Research Database. The diabetic severity was evaluated by the adapted Diabetes Complications Severity Index (aDCSI) from the prediabetic period to the end of follow-up. Cox proportional hazard regressions were used to calculate the hazard ratios (HRs) of the scores and change in the aDCSI.
Participants:
Participants were 431,178 new-onset diabetic patients who were older than 50 years and had to receive antidiabetic medications.
Main Outcome:
Dementia cases were identified by International Classification of Diseases, ninth revision, code (International Classification of Diseases, ninth revision, codes 290.0, 290.1, 290.2, 290.3, 290.4, 294.1, 331.0), and the date of the initial dementia diagnosis was used as the index date.
Results:
The scores and change in the aDCSI were associated with the risk of dementia when adjusting for patient factors, comorbidity, antidiabetic drugs, and drug adherence. At the end of the follow-up, the risks for dementia were 1.04, 1.40, 1.54, and 1.70 (P < .001 for trend) in patients with an aDCSI score of 1, 2, 3, and greater than 3, respectively. Compared with the mildly progressive patients, the adjusted HRs increased as the aDCSI increased (2 y HRs: 1.30, 1.53, and 1.97; final HRs: 2.38, 6.95, and 24.0 with the change in the aDCSI score per year: 0.51-1.00, 1.01-2.00, and > 2.00 vs < 0.50 with P < .001 for trend).
Conclusions:
The diabetic severity and progression reflected the risk of dementia, and the early change in the aDCSI could predict the risk of dementia in new-onset diabetic patients.
Related Concept Videos
01:15Diabetes: Symptoms, Diagnosis, and Complications
01:30Dementia
The progression of dementia is generally gradual....
01:19Psychoneuroimmunology: Diabetes and Cancer
01:22Diabetes Mellitus: Type 2 and Gestational
01:20Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
01:22Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...