A demonstration project implementing extended-release naltrexone in Los Angeles County
Sarah J Cousins1, Loretta Denering2, Desirée Crèvecoeur-MacPhail1
1a Integrated Substance Abuse Programs , University of California , Los Angeles , California , USA.
Substance Abuse
|July 10, 2015
Summary
Extended-release naltrexone (XR-NTX) is effective for treating alcohol and opioid use disorders. This project demonstrates the feasibility of integrating XR-NTX into real-world substance use disorder treatment settings.
Area of Science:
- Addiction Medicine
- Pharmacotherapy
- Public Health
Background:
- Extended-release naltrexone (XR-NTX) is FDA-approved for treating substance use disorders (SUDs).
- Limited data exists on the real-world implementation and patient uptake of XR-NTX.
- A demonstration project was established in Los Angeles County to enhance XR-NTX accessibility.
Purpose of the Study:
- To describe the implementation of a project increasing access to XR-NTX.
- To analyze patient uptake and characteristics of individuals receiving XR-NTX.
- To assess the feasibility of XR-NTX integration in community SUD treatment.
Main Methods:
- Secondary analysis of demographic and clinical data from 609 patients receiving XR-NTX (April 2010-July 2013).
- Evaluation of substance use history, current behaviors, and dosing records.
- Geographic Information System (GIS) mapping of XR-NTX referring agencies.
Main Results:
- A majority of patients (64%) received multiple XR-NTX doses.
- Alcohol use disorder was the most common condition (71.9%).
- XR-NTX recipients exhibited more severe substance use histories compared to general SUD patients.
- XR-NTX was accessible in 6 of 8 Los Angeles County Service Planning Areas.
Conclusions:
- The project demonstrated feasibility of engaging providers in XR-NTX use for alcohol and opioid use disorders.
- Findings suggest higher cessation rates and fewer doses compared to similar projects.
- Implications for future research and implementation strategies are discussed.
Keywords:
Alcohol use disorderXR-NTXevidence-based practiceimplementationmedication-assisted treatmentnaltrexoneopioid use disorderMore Related Videos
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