Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

10.2K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.2K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.9K
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The mitigatory capabilities of exercise on breast cancer chemotherapy-induced cardiotoxicity.

Frontiers in cell and developmental biology·2025
Same author

A two-stage genome-wide association study to identify novel genetic loci associated with irAEs in lung cancer patients receiving PD-1/PD-L1 inhibitors.

Cancer letters·2025
Same author

ROS homeostasis in cell fate, pathophysiology, and therapeutic interventions.

Molecular biomedicine·2025
Same author

Intestinal fungal signatures and their impact on immune checkpoint inhibitor efficacy: a multi-cohort meta-analysis.

NPJ biofilms and microbiomes·2025
Same author

Gut bacteria and the host synergies promote resveratrol metabolism and induce tolerance in ALD mice.

NPJ biofilms and microbiomes·2025
Same author

Correction: Mao et al. Huperzine A Ameliorates Cognitive Deficits in Streptozotocin-Induced Diabetic Rats. <i>Int. J. Mol. Sci</i>. 2014, <i>15</i>, 7667-7683.

International journal of molecular sciences·2025
Same journal

Turbulent flow in a vortex separator with a directed pipe inlet.

Scientific reports·2026
Same journal

Systematic characteristic evaluation of clay-based cementitious material derived from calcium carbide residue and waste tile powder.

Scientific reports·2026
Same journal

Retraction Note: Improvement of a rapid diagnostic application of monoclonal antibodies against avian influenza H7 subtype virus using Europium nanoparticles.

Scientific reports·2026
Same journal

Applying large language models to spam detection in the Kazakh low-resource language setting.

Scientific reports·2026
Same journal

An open-source 3D printing system enabling in-situ freeze-thaw processing of hydrogels.

Scientific reports·2026
Same journal

An enhanced EfficientNet framework for automated waste classification using cosine annealing and label smoothing.

Scientific reports·2026
See all related articles

Related Experiment Video

Updated: Apr 7, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

925

Genome-scale long noncoding RNA expression pattern in squamous cell lung cancer.

Ying Wang1, Chen-Yue Qian2, Xiang-Ping Li2

  • 11] Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008; P. R. China; Institute of Clinical Pharmacology, Central South University; Hunan Key Laboratory of Pharmacogenetics, Changsha 410078; P. R. China [2] The Affiliated Cancer Hospital of XiangYa School of Medicine, Central South University, Changsha, Hunan 410014, P. R. China.

Scientific Reports
|July 11, 2015
PubMed
Summary
This summary is machine-generated.

This study identified numerous differentially expressed long noncoding RNAs (lncRNAs) in squamous cell lung cancer (SQCC) tissues compared to normal tissues. These lncRNAs are linked to key cancer processes and may serve as future therapeutic targets for lung cancer.

More Related Videos

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
07:59

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer

Published on: September 8, 2023

1.8K
Author Spotlight: RNA FISH for Locating lncRNA-SNHG6 in Osteosarcoma Cells
05:27

Author Spotlight: RNA FISH for Locating lncRNA-SNHG6 in Osteosarcoma Cells

Published on: June 16, 2023

2.6K

Related Experiment Videos

Last Updated: Apr 7, 2026

Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

925
Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
07:59

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer

Published on: September 8, 2023

1.8K
Author Spotlight: RNA FISH for Locating lncRNA-SNHG6 in Osteosarcoma Cells
05:27

Author Spotlight: RNA FISH for Locating lncRNA-SNHG6 in Osteosarcoma Cells

Published on: June 16, 2023

2.6K

Area of Science:

  • Genomics
  • Molecular Biology
  • Oncology

Background:

  • Lung squamous cell carcinoma (SQCC) is a major subtype of lung cancer.
  • Understanding the molecular mechanisms, particularly the role of noncoding RNAs, is crucial for improving treatment strategies.

Purpose of the Study:

  • To investigate the genome-wide expression patterns of long noncoding RNAs (lncRNAs) in SQCC.
  • To identify differentially expressed lncRNAs and their potential association with tumor development and differentiation.

Main Methods:

  • RNA extraction from matched SQCC and normal lung tissues of 16 patients.
  • Genome-wide lncRNA and mRNA expression profiling using microarray.
  • Quantitative real-time PCR (qRT-PCR) for lncRNA expression validation in 47 patients.
  • Bioinformatic analysis including Gene Ontology (GO) and pathway analysis.

Main Results:

  • A significant number of differentially expressed lncRNAs were identified: 2,748 upregulated and 852 downregulated probes in tumor tissues.
  • Co-expressed mRNA analysis indicated enrichment in 'development and differentiation' (GO) and 'cell cycle' (pathway) categories.
  • Specific lncRNA expression patterns were observed in subgroups, including smoking status and tumor differentiation.

Conclusions:

  • Clusters of lncRNAs are significantly dysregulated in SQCC compared to matched normal tissues.
  • These dysregulated lncRNAs play a role in lung cancer development and progression.
  • Identified lncRNAs represent potential diagnostic biomarkers and therapeutic targets for SQCC.