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The Specificity of the WINROP Algorithm Can Be Significantly Increased by Reassessment of the WINROP Alarm

Pia Lundgren1, Elisabeth Stoltz Sjöström, Magnus Domellöf

  • 1Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Neonatology
|July 11, 2015
PubMed

Insights

Reassessing the weight at alarm in the WINROP system significantly improves its specificity for identifying extremely preterm infants who need retinopathy of prematurity treatment, while maintaining high sensitivity.

Area of Science:

  • Neonatal ophthalmology
  • Perinatal medicine
  • Medical technology

Background:

  • Retinopathy of prematurity (ROP) is a serious vision impairment affecting extremely preterm infants.
  • Newer ROP screening systems aim to enhance accuracy and reduce infant stress compared to existing guidelines.

Purpose of the Study:

  • To enhance the specificity of the WINROP (Weight, Insulin-like growth factor-I, Neonatal, ROP) surveillance system.
  • To accurately identify extremely preterm infants requiring ROP treatment.

Main Methods:

  • Reevaluated two existing cohorts (Swedish EXPRESS and North American) using WINROP analysis.
  • Determined 'safe' WINROP alarm weight limits for infants born before 27 weeks gestational age.

Main Results:

  • Specificity in the EXPRESS cohort increased from 23.9% to 35.0%.
  • Specificity in the North American cohort increased from 8.5% to 26.6%.
  • Sensitivity remained high at 97.5% (EXPRESS) and 98.3% (North American).

Conclusions:

  • Reassessing weight at WINROP alarm significantly improves system specificity.
  • This refinement aids in better identifying extremely preterm infants needing ROP treatment.
Abstract

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