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Updated: Apr 7, 2026

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury

Published on: August 14, 2019

Estimating Total Cerebral Microinfarct Burden From Diffusion-Weighted Imaging.

Eitan Auriel¹, M Brandon Westover¹, Matt T Bianchi¹

¹From the Department of Neurology, J. Philip Kistler Stroke Research Center (E.A., M.B.W., M.T.B., Y.R., S.M.-R., J.N., E.V.E., P.F., K.S., A. Vashkevich, G.B., M.E.G., A. Viswanathan, S.M.G.) and Department of Pathology, Neuropathology Service, C.S. Kubik Laboratory for Neuropathology (M.P.F.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown (A.P.Y., K.A.J., R.A.S., T.H.); and Department of Neurology, Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (R.A.S.).

|July 11, 2015

Summary

This summary is machine-generated.

Detecting even one diffusion-weighted imaging (DWI) lesion indicates hundreds of new cerebral microinfarcts (CMI) annually. These microinfarcts likely contribute to vascular cognitive impairment.

Keywords:

brain cerebral hemorrhage cerebral infarction diffusion magnetic resonance imaging mild cognitive impairment

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Published on: September 25, 2019

Area of Science:

Neurology
Neuroimaging
Pathology

Background:

Cerebral microinfarcts (CMI) are significant contributors to vascular cognitive impairment.
Diffusion-weighted imaging (DWI) hyperintensities are proposed indicators of acute CMI.

Purpose of the Study:

To develop a mathematical method for estimating the total number of CMIs.
To correlate incidental DWI lesions with CMI burden.

Main Methods:

Review of MRI scans from subjects with and without cognitive decline, including those with prior intracerebral hemorrhage (ICH).
Estimation of annual CMI rates based on DWI lesion characteristics.
Histological sampling of a deceased subject with prior ICH and a DWI lesion.

Main Results:

DWI lesions were found in 3.8% of cognitively impaired, 5% of cognitively intact, and 12.9% of ICH patients.
Predicted annual CMI incidence varied widely (16-1566 for non-ICH, 50-5041 for ICH).
Histological analysis estimated a total brain burden of 9321 CMIs.

Conclusions:

A single DWI lesion suggests hundreds of new CMIs per year.
Cumulative CMI burden may directly cause small-vessel vascular cognitive impairment.