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ROS1 rearranged non-small cell lung cancer brain metastases respond to low dose radiotherapy
Rimas V Lukas1, Yasmin Hasan2, Martin K Nicholas3
1Department of Neurology, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA.
Abstract:
We present a young woman with ROS1 gene rearranged non-small cell lung cancer (NSCLC) with brain metastases. ROS is a proto-oncogene tyrosine protein kinase. The patient received a partial course of whole brain radiation therapy and experienced a sustained partial response in the brain. We hypothesize that ROS1 rearranged NSCLC brain metastases may be particularly sensitive to radiation therapy.
