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A Novel Clinical Grade Isolation Method for Human Kidney Perivascular Stromal Cells
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Stem cell therapy for kidney disease.

Elena Lazzeri1, Paola Romagnani1, Laura Lasagni1

  • 1a University of Florence; Excellence Centre for Research, Transfer and High Education for the Development of DE NOVO Therapies (DENOTHE) , Florence, Italy +390552758342 ; elena.lazzeri@unifi.it ; laura.lasagni@unifi.it.

Expert Opinion on Biological Therapy
|July 11, 2015
PubMed
Summary

Stem cell therapy shows promise for kidney disease, particularly using mesenchymal stem cells. Further research is needed to confirm efficacy in human trials and explore modulating the kidney

Keywords:
mesenchymal stem cellsregenerative medicinerenal progenitor cellsstem cells

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Area of Science:

  • Regenerative Medicine
  • Nephrology
  • Stem Cell Biology

Background:

  • Kidney diseases represent a growing global health concern, exacerbated by aging populations and comorbidities like hypertension and diabetes.
  • The increasing incidence of kidney disease necessitates novel therapeutic strategies beyond current treatment limitations.

Purpose of the Study:

  • To review the therapeutic potential of various stem cell types for treating kidney diseases.
  • To evaluate the application of mesenchymal stem cells in preclinical and clinical settings for renal repair.
  • To explore the endogenous regenerative capacity of the kidney and methods to enhance it.

Main Methods:

  • Comprehensive review of preclinical and clinical studies involving stem cell therapy for kidney diseases.
  • Detailed analysis of mesenchymal stem cell applications and their documented outcomes.
  • Examination of research on endogenous kidney regeneration and pharmacological modulation strategies.

Main Results:

  • Stem cell therapy demonstrates significant promise in numerous animal models of kidney disease.
  • Mesenchymal stem cells are identified as a leading candidate cell type, though clinical trial results remain debated.
  • The discovery of progenitor cells in adult kidneys suggests intrinsic repair potential.

Conclusions:

  • Stem cell therapy offers a promising avenue for treating kidney disease, supported by extensive animal data.
  • Clinical translation of mesenchymal stem cell therapy requires further validation to confirm efficacy and safety.
  • Targeting endogenous renal progenitors presents a novel strategy for in situ kidney regeneration and treatment.