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APPLIED PHYSICS. Mid-infrared plasmonic biosensing with graphene.

Daniel Rodrigo1, Odeta Limaj1, Davide Janner2

  • 1Institute of BioEngineering, École Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland.

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Summary

Graphene plasmonics enable highly sensitive, label-free biosensing of proteins. This tunable sensor enhances light interaction with small molecules, improving detection of their chemical fingerprints.

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Area of Science:

  • Plasmonics
  • Biosensing
  • Nanomaterials

Background:

  • Infrared spectroscopy identifies biomolecules via vibrational fingerprints.
  • Infrared light poorly interacts with nanometric molecules, limiting detection sensitivity.
  • Graphene's unique electro-optical properties offer potential for enhanced biosensing.

Purpose of the Study:

  • To demonstrate a high-sensitivity tunable plasmonic biosensor using graphene.
  • To achieve chemically specific, label-free detection of protein monolayers.
  • To leverage graphene's properties for improved biomolecule detection.

Main Methods:

  • Utilizing nanostructured graphene with tunable plasmon resonance.
  • Dynamically tuning plasmon resonance to probe proteins at specific frequencies.
  • Extracting the complex refractive index of proteins.

Main Results:

  • Demonstrated a high-sensitivity tunable plasmonic biosensor for protein monolayers.
  • Achieved chemically specific, label-free detection.
  • Exploited graphene's extreme light confinement for superior overlap with nanometric biomolecules.

Conclusions:

  • Graphene-based plasmonic biosensors offer enhanced sensitivity for detecting biomolecules.
  • Tunable spectral selectivity and light confinement in graphene are key to improved biosensing.
  • This technology opens new avenues for advanced biosensing applications.