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Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

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LIF is a new p53 negative regulator.

Juan Liu1, Haiyang Yu1, Wenwei Hu1

  • 1Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, Rutgers, State University of New Jersey, New Brunswick, NJ, USA.

Journal of Nature and Science
|July 11, 2015
PubMed
Summary

Leukemia inhibitory factor (LIF) negatively regulates the tumor suppressor p53 in colorectal cancer by activating Stat3 and ID1, promoting chemoresistance. LIF overexpression correlates with poor prognosis in cancer patients.

Keywords:
ID1LIFMDM2Stat3chemoresistancep53

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