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The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
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Related Experiment Video

Updated: Apr 7, 2026

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
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Salivary Urease and ADS Enzymatic Activity as Endogenous Protection against Dental Caries in Children.

G Moncada, J Maureira, M Neira

    The Journal of Clinical Pediatric Dentistry
    |July 11, 2015
    PubMed
    Summary
    This summary is machine-generated.

    Salivary ureolytic activity was significantly linked to lower dental caries in 8-year-olds. Higher urease enzyme levels correlated with fewer caries, suggesting a protective role for this oral bacteria activity.

    Keywords:
    ADSDMFT/dmftargininacarieschildrenureaurease

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    Area of Science:

    • Oral Health
    • Microbiology
    • Biochemistry

    Background:

    • Dental caries remains a significant global health issue, particularly in pediatric populations.
    • Salivary enzymes play a crucial role in maintaining oral homeostasis and influencing caries development.
    • Ureolytic and arginolytic activities in saliva are implicated in buffering acids and modulating the oral environment.

    Purpose of the Study:

    • To investigate the ureolytic and arginolytic enzyme activities in the saliva of 8-year-old children.
    • To determine the association between these salivary enzyme activities and the children's dental caries status, assessed by DMFT and dmft indices.

    Main Methods:

    • A cross-sectional study involving 65 eight-year-old children.
    • Non-stimulated saliva samples were collected after a 12-hour fasting and no oral hygiene period.
    • Ureolytic and arginolytic activities were measured and correlated with caries severity (DMFT/dmft index) categorized into three groups.

    Main Results:

    • A statistically significant inverse relationship was observed between ureolytic activity and caries status (p=0.048).
    • Children with higher ureolytic activity showed lower DMFT/dmft scores.
    • Arginine deiminase activity did not show a statistically significant association with caries status (p=0.16).

    Conclusions:

    • Elevated salivary ureolytic activity is associated with a reduced prevalence of dental caries in 8-year-old children.
    • While not statistically significant, a trend suggested higher arginolytic activity also correlated with lower caries scores.
    • The findings highlight the potential protective role of ureolytic enzymes in preventing dental caries.