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Updated: Apr 7, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Association between polymorphisms in IL27 gene and renal cell carcinoma
1a Department of Forensic Biology , West China School of Preclinical and Forensic Medicine, Sichuan University , Chengdu , Sichuan , P.R. China .
Context:
Interleukin-27 is a new member of the IL-12 family which plays an important role in human carcinogenesis.
Objective:
To investigate whether polymorphisms in IL27 contribute to renal cell carcinoma (RCC) risk.
Materials And Methods:
These two polymorphisms were genotyped in 329 RCC patients and 386 healthy controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
Results:
Significantly increased RCC risk was associated the G allele of both rs153109 and rs17855750 (rs153109: p = 0.006, OR = 1.364, 95%CI = 1.095-1.700; rs17855750: p = 0.001, OR = 1.768, 95%CI = 1.245-2.511).
Conclusion:
The present study provided evidence that rs153109 and rs17855750 were associated with increased risk for RCC, suggesting an important role IL-27 may play in nephrocarcinogenesis.
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